To systematically investigate the crystallization behaviour of drug substances, Pharmaterials offers a range of conventional and high-throughput screening platforms designed around the properties of the molecule under study as well as the budget and timeframes available to our clients. Since most of the candidate drug substances for screening are in the early stages of drug development (preclinical to phase I clinical trials), our crystallization screening and analytical technology is scaled down to ensure minimise sample use.
High throughput screening (HTS)
THE PHARMATERIALS ADVANTAGE:
- We have state-of-the-art instrumentation including a 96 well plate reading TRANSMISSION X-ray diffractometer which can detect across a wide range of 2 theta angles, for a small sample mass, with excellent sensitivity.
- Outstanding chemometrics – our data processing and cluster analysis software allows information to be gained rapidly and reliably for different forms in our 96 well plate studies.
- Two techniques are better than one! – we use our 96 well plate on our transmission X-ray and also on our plate reading Raman microscope. Two different methods, two different data analysis chemometric clustering systems and then cross referencing of findings for confirmation of hits = A very reliable rapid screen results.
The outcome: We can do a high throughput 300 solvent screen on less than 500 mg of material, crystallize, do the full analysis and report the data in 5 working days!! This outstanding industry leading performance is all part of the advantage of the Pharmaterials experience.
Medium throughput screening (MTS)
There are customers who wish to have work carried out with scientist involvement in every step of the screen.
Whilst our HTS screen is an outstanding way of developing large amounts of reliable data, there is comfort in having one of our experts handle the material, deal with the crystallizations and data interpretation.
We are delighted to provide a high quality service with our expert scientific team working on your projects.
With a minimal amount of product, we can screen a broad and diverse parameter space in a short space of time. Intelligent experimental planning and procedures yield an impressive throughput of conditions and results reported in a week or two (depending on the size of screen required).
Low throughput screening and scale up
The final stage of any screen will be to scale up and define the crystallization conditions and carry out a full characterization of the polymorphs including DSC, TGA, X-ray (powder and single crystal if required), GVS, intrinsic solubility and a range of other tests as agreed with the client.
We will do this rapidly and efficiently and provide the information you need with the advice that helps you make decisions on your development programme.
Please contact us for more details