Professor Graham Buckton is a pioneer in the field of amorphous content studies. The methods developed by Graham have been established in Pharmaterials and our scientists are experts in their use and interpretation.
We firmly believe that there is no one best method, rather that each case should be judged on its merits and the best method selected for your needs. Those who have only one method to offer will tell you that it is the best, but the reality is that you should consider various options.
The methods:
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isothermal nanocalorimetry - using a vapour to cause the amorphous content to crystallise. We know the strenghts and weaknesses of this method and will advise accordingly. We provide both sealed ampoule and gas perfusion methods.
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gravimtric vapour sorption - and excellent method to detect amorphous content, we offer water and organic vapour sudies
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NIR spectroscopy - an excellent method especially when we use our UNIQUE hyphonated DVS-NIR system (simultaneous gravimetric sorption and NIR to give two methods to detect and quantify)
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Raman spectroscopy - another excellent method for amorphous quantification / detection
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Hyper DSC - whilst conventional DSC methods fail to detect amorphous content, fast scan (500 C / min) is able to detect very low quantities of amorphous content
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X-ray diffraction - most diffraction systems cannot detect low levels of amorphous content, but Pharmaterials have the latest PANalytical X Celerator detector, giving detection of changes in form to c 1%
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Solution calorimetry - using the difference between the enthalpy of solution of the amorphous and crystalline forms this can be a very sensitive method, if performed correctly.
All these methods have a place - our experience will help you understand their pros and cons - we don't just measure we understand
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