Pharmaterials Ltd The Queen's Awards for Enterprise 2008
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Home | COMPANY    |     POLYMORPHS/SALTS/CO-CRYSTALS    |     PREFORMULATION / FORMULATION    |     CONSULTANCY    |     GMP MANUFACTURE    |     PHYS PROPS    |     INHALATION    |    
Polymorphs/Salts/Co-crystals
Polymorph Screening Amorphous Content Screening Pharmaceutical Co-crystals Raman Mapping / Chemical Imaging Crystallisation of amorphous material Salt screening / salt selection Developability screen Formulation screen Pharmaceutical Quality by Design (QbD)

Controlled Release

Controlled release of the active ingredient from the formulation vehicle can often be achieved through the inclusion of simple or complex polymer coatings and matrix systems. However, small changes in the formulation make up, such as polymer grade etc, can often result in great variability of the product performance compared to the original form

Our combination of high resolution imaging and chemical spectroscopy techniques can rapidly assist in the development and protection of optimised processing parameters, reducing the chances of late stage product failure and time wasted identifying the cause.

Types of analysis include:

  • Chemical identification of components
  • Spatial mapping & quantification of components
  • Film coating integrity & thickness determination
  • Identification of component migration/segregation & contamination
  • In-situ identification of drug form within polymer matrices
  • Identification of polymer & drug degradation
Controlled release
APPLICATION AREAS:
  • API & excipient solid-state testing
  • Solid dosage forms
  • Controlled release
  • Inhalation / respiratory drug delivery2
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