Solid Dosage Forms
In most cases, failure in final product stability, dissolution and bioavailability can be in part correlated back to changes in the physicochemical properties of the API and formulation components as a result of physical processing or unsuitable manufacturing procedures.
At Pharmaterials, we have the experience and technology to rapidly understand the complexity of the whole dosage form to gain greater fundamental understanding of batch to batch variability, unexpected drug release profiles and failure during stability trials.
Types of analysis include:
Spatial mapping & identification of individual components (Chemical imaging)
In-situ identification of polymorphic form and/or polymorphic form changes
In-situ assessment of interaction & degradation
Identification of component migration/segregation & contamination