Pharmaterials Ltd The Queen's Awards for Enterprise 2008
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Home | COMPANY    |     POLYMORPHS/SALTS/CO-CRYSTALS    |     PREFORMULATION / FORMULATION    |     CONSULTANCY    |     GMP MANUFACTURE    |     PHYS PROPS    |     INHALATION    |    
Polymorphs/Salts/Co-crystals
Polymorph Screening Amorphous Content Screening Pharmaceutical Co-crystals Raman Mapping / Chemical Imaging Crystallisation of amorphous material Salt screening / salt selection Developability screen Formulation screen Pharmaceutical Quality by Design (QbD)

Techniques Available

Pharmaterials has a wide range of instrumentation including inverse gas chromatography (IGC), thermal analysis (Hyper-DSC, isothermal calorimetry, solution calorimetry, high sensitivity DSC), confocal Raman mapping, DVS,  X-ray diffraction, surface area, particle sizing and many more.  Some examples are listed below:

Chromatography
HPLC-UV/ELSD

Diffraction Studies
X-ray powder diffraction, single crystal X-ray for structure resolution

Thermal Methods
DSC, Hyper-DSC, TGA, Isothermal nanocalorimetry, Solution calorimetry, High sensitivity scanning calorimetry

Microscopy
Optical, Raman, SEM, Hot-stage

Sorption/Desorption Studies
Water and organic vapour (coupled NIR probe), Nitrogen BET

Powder Surface Characterisation
Inverse gas chromatography, Confocal Raman spectroscopy

Bulk Properties Determination
Specific surface area, porosity, bulk and tapped density, powder flow

Dissolution Testing
Intrinsic and non-intrinsic methods, USP Apparatus 4 flow through dissolution testing, HPLC, UV, ELSD analysis

Techniques Available

State of the art:

Thermal analysis

Surface science

Physical form

Preformulation

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